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KMID : 0854720070270030186
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 3 p.186 ~ p.189
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A Case of IgA-Associated Leukocytoclastic Vasculitis Treated with Dapsone in the Elderly
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Kwon Jae-Woo
Park Heung-Woo
Sohn Seong-Wook
Kim Sun-Sin
Chang Yoon-Seok
Cho Sang-Heon
Min Kyung-Up
Kim You-Young
Kim Tae-Wan
Kim Deok-In
Park Chang-Han
Kim Min-Hye
Park Han-Ki
Lim Kyung-Hwan
Yang Min-Suk
Lee So-Hee
Kwon Hyouk-Soo
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Abstract
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We report a case of elderly patient with IgA-associated leukocytoclastic vasculitis who was successfully treated with dapsone. A 75-year-old Korean female patient who had suffered from asthma visited because of multiple purpura, vesicle, and bullae on her extremities. She also complained of pitting edema, especially on the lower extremities. She was diagnosed as IgA-associated leukocytoclastic vasculitis by skin biopsy and treated successfully with steroid. How- ever, skin lesions recurred after tapering steroid. We restarted high-dose steroid and the lesions showed improvement. However, skin lesions were refractory to lower-dose steroids, and also refractory to colchicine treatment. Dapsone (50 mg daily) induced dramatic improvement of her cutaneous vasculitis, proteinuria and edema.
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KEYWORD
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IgA, vasculitis, Henoch-Schonlein purpura, dapsone
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